Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5980885

Title:Growth factor-induced proliferation of neural precursor cells in vivo
Inventors:Weiss, Samuel; Alberta, Canada
Reynolds, Brent; Alberta, Canada
Summary:Described herein are in vivo methods of inducing neural cell proliferation by the administration of growth factors. The invention relates to mammalian precursor cells and the induction of their proliferation via the administration of a fibroblast growth factor and at least one additional growth factor selected from the group consisting of epidermal growth factor, transforming growth factor alpha, and amphiregulin. Therapeutic applications are included for the replacement of damaged neurons and glia, for the transplantation of multipotent neural stem cell progeny into a mammal, and for treatment of neurological, neurodegenerative and central nervous system disorders.
Abstract:A method is described for inducing in vivo proliferation of precursor cells located in mammalian neural tissue by administering to the mammal a fibroblast growth factor and at least one additional growth factor selected from the group consisting of epidermal growth factor, transforming growth factor alpha, and amphiregulin. The method can be used to replace damaged or missing neurons and/or glia. Another method is described for transplanting multipotent neural stem cell progeny into a mammal. The method comprises the steps of administering growth factors to a mammal to induce in vivo proliferation of neural precursor cells, removing the precursor cell progeny from the mammal, culturing the removed cells in vitro in the presence of one or more growth factors that induces multipotent neural stem cell proliferation, and implanting the multipotent neural stem cell progeny into the mammal.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5980885
Application Number:US1995000486307
Date Filed:07/06/1995
Date Published:09/11/1999
Assignee:NeuroSpheres Holdings Ltd., Calgary, Canada


 
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