|
|
|
Stem Cell Related Patent Number US5981830
| Title: | Knockout mice and their progeny with a disrupted hepsin gene | | Inventors: | Wu, Qingyu; El Sobrante, CA, USA
Sadler, Jasper E.; St. Louis, MO, USA | | Summary: | This invention introduces transgenic nonhuman mammals which are homozygotic for the hepsin gene. Described herein are methods of producing a transgenic mouse comprised of a disrupted hepsin gene via a process of utilizing a hepsin targeting vector for homologous recombination in mouse embryonic stem cells. Claims of the invention include a mouse which exhibits elevated blood serum alkaline phosphatase levels when compared to levels of wild-type mice. Specific nucleotide and amino acid hepsin sequences are provided, as are therapeutic and experimental applications of such an animal model in the treatment of bone diseases. | | Abstract: | The present invention provides a transgenic mouse comprising a disrupted hepsin gene. In particular, the invention provides methods of making the transgenic mouse comprising the disrupted hepsin gene by utilizing a hepsin targeting vector for homologous recombination in mouse embryonic stem cells. Also, nucleotide and amino acid hepsin sequences are disclosed. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US5981830 | | Application Number: | US1997000000846 | | Date Filed: | 30/12/1997 | | Date Published: | 09/11/1999 | | Assignee: | Schering Aktiengesellschaft, Berlin, Germany
Washington University, St. Louis, MO, USA |
|
|
