Methods comprising apoptosis inhibitors for the generation of transgenic pigs

Stem Cell Clinic
Patient Application
FAQ
Contact
Locations
News
Videos
Research
Patents
3D Culture/Scaffold
Administration
Differentiation
Expansion
Extraction/Preservation
Mobilization
Type
USE
 


Stem Cell Related Patent Number US5981830

Title:Knockout mice and their progeny with a disrupted hepsin gene
Inventors:Wu, Qingyu; El Sobrante, CA, USA
Sadler, Jasper E.; St. Louis, MO, USA
Summary:This invention introduces transgenic nonhuman mammals which are homozygotic for the hepsin gene. Described herein are methods of producing a transgenic mouse comprised of a disrupted hepsin gene via a process of utilizing a hepsin targeting vector for homologous recombination in mouse embryonic stem cells. Claims of the invention include a mouse which exhibits elevated blood serum alkaline phosphatase levels when compared to levels of wild-type mice. Specific nucleotide and amino acid hepsin sequences are provided, as are therapeutic and experimental applications of such an animal model in the treatment of bone diseases.
Abstract:The present invention provides a transgenic mouse comprising a disrupted hepsin gene. In particular, the invention provides methods of making the transgenic mouse comprising the disrupted hepsin gene by utilizing a hepsin targeting vector for homologous recombination in mouse embryonic stem cells. Also, nucleotide and amino acid hepsin sequences are disclosed.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5981830
Application Number:US1997000000846
Date Filed:30/12/1997
Date Published:09/11/1999
Assignee:Schering Aktiengesellschaft, Berlin, Germany Washington University, St. Louis, MO, USA


 
Copyright © 2007 The Institute for Cellular Medicine  8/4/2020