Methods comprising apoptosis inhibitors for the generation of transgenic pigs

Stem Cell Clinic
Patient Application
FAQ
Contact
Locations
News
Videos
Research
Patents
3D Culture/Scaffold
Administration
Differentiation
Expansion
Extraction/Preservation
Mobilization
Type
USE
 


Stem Cell Related Patent Number US5985276

Title:Destruction of contaminating tumor cells in stem cell transplants using bispecific antibodies
Inventors:Lindhofer, Horst; Grobenzell, Germany
Menzel, Helge; Munchen, Germany
Kolb, Hans-Jochem; Munchen, Germany
Thierfelder, Stefan; Eichenau, Germany
Summary:This invention describes methods for the destruction of tumor cells in stem cell grafts via the use of a bispecific antibody. Disclosed herein is a procedure for the ex vivo destruction of contaminating tumor cells in stem cell transplants using intact bispecific antibodies which are capable of binding to the T cell receptor complex of a T cell, and to the Fc-receptor of a Fc-receptor positive cell, and to tumor-associated antigens on a tumor cell. Claims of the invention include a subsequent activation of the T cells and a redirection of the T cells and the Fc-receptor positive cells to the tumor cells, resulting in the destruction of the tumor cells. Specific therapeutic applications in the treatment of tumors are included.
Abstract:The present invention discloses a procedure for the destruction of contaminating tumor cells in stem cell transplants ex vivo using intact bispecific antibodies.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5985276
Application Number:US1997000922966
Date Filed:03/09/1997
Date Published:16/11/1999
Assignee:GSF Forschungszentrum fur Umwelt und Gesundheit GmbH, Oberschleissheim, Germany


 
Copyright © 2007 The Institute for Cellular Medicine  8/13/2020