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Stem Cell Related Patent Number US5985276
| Title: | Destruction of contaminating tumor cells in stem cell transplants using bispecific antibodies | | Inventors: | Lindhofer, Horst; Grobenzell, Germany
Menzel, Helge; Munchen, Germany
Kolb, Hans-Jochem; Munchen, Germany
Thierfelder, Stefan; Eichenau, Germany | | Summary: | This invention describes methods for the destruction of tumor cells in stem cell grafts via the use of a bispecific antibody. Disclosed herein is a procedure for the ex vivo destruction of contaminating tumor cells in stem cell transplants using intact bispecific antibodies which are capable of binding to the T cell receptor complex of a T cell, and to the Fc-receptor of a Fc-receptor positive cell, and to tumor-associated antigens on a tumor cell. Claims of the invention include a subsequent activation of the T cells and a redirection of the T cells and the Fc-receptor positive cells to the tumor cells, resulting in the destruction of the tumor cells. Specific therapeutic applications in the treatment of tumors are included. | | Abstract: | The present invention discloses a procedure for the destruction of contaminating tumor cells in stem cell transplants ex vivo using intact bispecific antibodies. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US5985276 | | Application Number: | US1997000922966 | | Date Filed: | 03/09/1997 | | Date Published: | 16/11/1999 | | Assignee: | GSF Forschungszentrum fur Umwelt und Gesundheit GmbH, Oberschleissheim, Germany |
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