Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5985656

Title:Suppressor and progenitor cells
Inventors:Strober, Samuel S.; Portola Valley, CA, USA
Summary:Described herein are human double negative suppressor and progenitor cells, methods and uses thereof. The invention relates to natural suppressor (NS) cells which secrete a soluble protein suppressor factor (SF) which in turn suppresses the mixed lymphocyte response. Specifically disclosed herein are NS cells with the phenotypes IL-2R+, CD3-, CD4-, CD8-, TCR?a?-, Ig-, and MAC-1-, or which are double negative suppressors (DNS) and have the phenotypes IL-2R+, CD3+, CD4-, CD8-, and TCR?a?+. Claims of the invention include uses of both NS and SF in vivo to confer immunotolerance with respect to allogeneic transplants, to effect immunosuppression, and to enhance engraftment of transplanted cells. Also provided are density gradient separation techniques for enriching progenitor cells as identified by the presence of CD34 surface markers. Therapeutic applications include immunosuppression in the treatment and suppression of graft-versus-host disease or transplant rejection.
Abstract:
US Patent Website:Click Here for Full Text of Patent
Title Number:US5985656
Application Number:US1992000971723
Date Filed:04/11/1992
Date Published:16/11/1999
Assignee:The Board of Trustees of the Leland Stanford Junior University, Stanford, CA, USA


 
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