Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5986056

Title:Chordin compositions
Inventors:LaVallie, Edward R.; Tewksbury, MA, USA
Racie, Lisa A.; Acton, MA, USA
DeRobertis, Edward M.; Pacific Palisades, CA, USA
Summary:This invention introduces nucleic acids encoding a purified human chordin polypeptide, methods and uses thereof. Described herein are purified chordin proteins and the DNA molecules encoding the chordin proteins. Claims of the invention include the use of such proteins in inducing the inhibition of growth and differentiation of undifferentiated embryonic and other stem cells. Specific amino acid sequences are provided, as are methods by which the proteins may be complexed with other proteins, such as with members of the transforming growth factor-beta superfamily of proteins. Therapeutic applications are included in wound healing and in tissue regeneration, particularly in the treatment of disorders of the bone, cartilage, and other connective tissue, including cardiac, hepatic, pancreatic, neurological and renal tissue. This invention represents a continuation of other applications filed by the same assignee and inventors.
Abstract:Purified chordin proteins and processes for producing them are disclosed. DNA molecules encoding the chordin proteins are also disclosed. The proteins may be used in the treatment of bone, cartilage, other connective tissue defects and disorders, including tendon, ligament and meniscus, in wound healing and related tissue repair, as well for treatment of disorders and defects to tissue which include epidermis, nerve, muscle, including cardiac muscle, and othe tissues and wounds, and organs such as liver, brain, lung, cardiac, pancreas and kidney tissue. The proteins may also be useful for the induction inhibition of growth and/or differentiation of undifferentiated embryonic and stem cells. The proteins may be complexed with other proteins, particularly members of the transforming growth factor-beta superfamily of proteins.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5986056
Application Number:US1998000130032
Date Filed:04/08/1998
Date Published:16/11/1999
Assignee:None


 
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