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Stem Cell Related Patent Number US5997865
| Title: | Agonist antibodies against the flk2/flt3 receptor and uses thereof | | Inventors: | Bennett, Brian D.; South San Francisco, CA 94080 | | Summary: | This is a method for enhancing proliferation or differentiation of hematopoietic cells by contacting the hematopoietic cells with an effective amount of an agonist antibody which binds to the extracellular domain of flk2/flt3 and which activates the tyrosine kinase domain of flk2/flt3. Agonist antibodies are described which bind to the extracellular domain of the flk2/flt3 receptor and thereby activate the intracellular kinase domain. The labeled antibodies are useful as diagnostics for detecting the presence of the flk2/flt3 receptor in primitive hematopoietic cells, and they are able to cause primitive hematopoietic cells to proliferate and/or differentiate and thereby enhance repopulation of mature blood cell lineages in a mammal which has undergone chemo- or radiation therapy or bone marrow transplantation. The antibodies are also useful for treating mammals which have suffered a decrease in blood cells as a consequence of disease or a hemorrhage, among other disorders. | | Abstract: | Agonist antibodies are disclosed which bind to the extracellular domain of the flk2/flt3 receptor and thereby activate the intracellular kinase domain thereof. The labeled antibodies are useful as diagnostics for detecting the presence of the flk2/flt3 receptor in primitive hematopoietic cells for example. The antibodies are able to cause primitive hematopoietic cells to proliferate and/or differentiate and thereby enhance repopulation of mature blood cell lineages in a mammal which has undergone chemo- or radiation therapy or bone marrow transplantation. The antibodies are further useful for treating mammals which have suffered a decrease in blood cells as a consequence of disease or a hemorrhage, for example. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US5997865 | | Application Number: | US1995000434878 | | Date Filed: | 04/05/1995 | | Date Published: | 07/12/1999 | | Assignee: | None |
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