Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6001606

Title:Polynucleotides encoding myeloid progenitor inhibitory factor-1 (MPIF-1) and polypeptides encoded thereby
Inventors:Ruben, Steven M.; Olney, MD, USA
Li, Haodong; Gaithersburg, MD, USA
Summary:Described herein are novel truncated human chemokine beta-8 polypeptides, methods and uses thereof. The invention relates to the therapeutic uses of such compositions in isolating nucleic acid molecules that encode a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine ?8(CK?8 or ckb-8)), as well as a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-? and chemokine ?1(CK?1 or ckb-1)), a macrophage inhibitory protein-4 (MIP-4), and MPIF-1, M-CIF or MIP-4 polypeptides themselves. Further disclosed are properties of vectors and host cells utilized herein, and recombinant methods for their production. Therapeutic applications are included in the protection of bone marrow stem cells from chemotherapeutic agents, and in the stimulation and acceleration of wound healing.
Abstract:There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine .beta.8(CK.beta.8 or ckb-8)); a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-.gamma. and chemokine .beta.1(CK.beta.1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6001606
Application Number:US1996000722719
Date Filed:30/09/1996
Date Published:14/12/1999
Assignee:Human Genome Sciences, Inc., Rockville, MD, USA


 
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