| Title: | Methods for differentiating neural stem cells to neurons or smooth muscle cells using TGT-.beta. super family growth factors |
| Inventors: | Anderson, David J.; Altadena, CA, USA |
| Summary: | This invention introduces in vitro methods for producing a population of mammalian neurons or smooth muscle cells via a process of contacting at least one mammalian neural stem cell with a growth factor which is a member of the transforming growth factor-? (TGF-?) superfamily of growth factors. Also provided are methods of detecting the differentiation of stem cells to a population of neurons or smooth muscle cells. A variety of experimental and therapeutic applications are included. |
| Abstract: | Method for producing a population of mammalian neurons and/or smooth muscle cells comprising contacting at least one mammalian neural stem cell with a culture medium containing one or more growth factors from the TGF-.beta. super family and detecting the differentiation of stem cell to a population of neurons or smooth muscle cells. |
| US Patent Website: | Click Here for Full Text of Patent |
| Title Number: | US6001654 |
| Application Number: | US1997000846028 |
| Date Filed: | 25/04/1997 |
| Date Published: | 14/12/1999 |
| Assignee: | California Institute of Technology, Pasadena, CA, USA |
