Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6010696

Title:Enhancing hematopoietic progenitor cell engraftment using mesenchymal stem cells
Inventors:Caplan, Arnold I.; Cleveland Heights, OH, USA
Haynesworth, Stephen E.; Cleveland Heights, OH, USA
Gerson, Stanton L.; Pepper Pike, OH, USA
Lazarus, Hillard M.; Shaker Heights, OH, USA
Summary:This invention introduces methods of enhanced hematopoietic progenitor cell engraftment in a human via the administration of isolated homogenous mesenchymal stem cells in combination with hematopoietic progenitor cells. Further disclosed are methods of culturally expanding the mesenchymal stem cell preparation and hematopoietic progenitor cells, such that the mesenchymal stem cells are then administered in an amount sufficient to promote engraftment of the hematopoietic progenitor cells.
Abstract:Method and preparations for enhancing hematopoietic progenitor cell engraftment in an individual by administering (i) a culturally expanded mesenchymal stem cell preparation and (ii) hematopoietic progenitor cells. The mesenchymal stem cells are administered in an amount effective to promote engraftment of the hematopoietic progenitor cells.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6010696
Application Number:US1998000047950
Date Filed:25/03/1998
Date Published:04/01/2000
Assignee:Osiris Therapeutics, Inc., Baltimore, MD, USA


 
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