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Stem Cell Related Patent Number US6015542
| Title: | Radioimmunotherapy of lymphoma using anti-CD20 antibodies | | Inventors: | Kaminski, Mark S.; Ann Arbor, MI, USA
Butchko, Gregory M.; Miami Lakes, FL, USA
Glenn, Stephan D.; Davie, FL, USA
Wahl, Richard L.; Ann Arbor, MI, USA | | Summary: | Described herein are novel compositions containing radiolabeled anti-CD20 monoclonal antibodies. The invention relates specifically to the treatment of B-cell lymphoma by such compositions, via the administration to a patient of both unlabeled antibodies and antibodies labeled with a radioisotope. Claims of the invention include advantageous tumor responses without severe myelosuppression, which are obtainable by this method in radiometric dosage ranges that do not require hematopoietic stem cell replacement as an adjunct therapy. | | Abstract: | Methods for the treatment of lymphoma by administration of a B cell-specific antibody are described. The invention encompasses providing to a patient both unlabeled antibodies and antibodies labeled with a radioisotope. A principal advantage of the method is that tumor responses can be obtained in a radiometric dose range that does not require hematopoietic stem cell replacement as an adjunct therapy also described is a composition useful in the treatment of lymphoma. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6015542 | | Application Number: | US1996000711527 | | Date Filed: | 10/09/1996 | | Date Published: | 18/01/2000 | | Assignee: | Coulter Pharmaceutical, Inc., South San Francisco, CA, USA
The Regents of the University of Michigan, Ann Arbor, MI, USA |
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