Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6027917

Title:Bone morphogenetic protein (BMP)-17 and BMP-18 compositions
Inventors:Celeste, Anthony J.; Hudson, MA, USA
Summary:This invention introduces the novel purified bone morphogenic protein-17 and -18 (BMP-17 and BMP-18) polypeptides, methods and uses thereof. Further disclosed are properties of the DNA molecules encoding the BMP-17 and BMP-18 proteins, as well as methods by which the proteins maybe utilized for inducing the growth and differentiation of undifferentiated embryonic stem cells. Therapeutic applications include the use of such proteins in the treatment of disorders of the bone, cartilage, and other connective tissue, including cardiac, hepatic, neurological and renal tissue.
Abstract:Purified BMP-17 and BMP-18 proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-17 and BMP-18 proteins are also disclosed. The proteins may be used in the treatment of bone, cartilage, other connective tissue defects and disorders, including tendon, ligament and meniscus, in wound healing and related tissue repair, as well as for treatment of disorders and defects to tissues which include epidermis, nerve, muscle, including cardiac muscle, and other tissues and wounds, and organs such as liver, lung, epithelium, brain, spleen, cardiac, pancreas and kidney tissue. The proteins may also be useful for the induction of growth and/or differentiation of undifferentiated embryonic and stem cells.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6027917
Application Number:US1997000987904
Date Filed:10/12/1997
Date Published:22/02/2000
Assignee:Genetics Institute, Inc., Cambridge, MA, USA


 
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