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Stem Cell Related Patent Number US6030836
| Title: | Vitro maintenance of hematopoietic stem cells | | Inventors: | Thiede, Mark A.; Forest Hill, MD, USA
Pittenger, Mark F.; Severna Park, MD, USA
Mbalaviele, Gabriel; Columbia, MD, USA | | Summary: | Described herein are methods of maintaining human hematopoietic stem cells in vitro. The invention relates to human mesenchymal stem cells and human mesenchymal stem cell-derived adipocytes that have been isolated from a tissue specimen such as bone marrow cells, and which are then co-cultured with hematopoietic progenitor cells such that the hematopoietic stem cells retain their phenotype. Therapeutic applications in the treatment of hematopoietic disorders are included. | | Abstract: | The present invention is directed to human mesenchymal stem cells isolated from a tissue specimen, such as marrow cells, and to the method of co-culturing isolated mesenchymal stem cells and/or mesenchymal stem cell-derived adipocytes with hematopoietic progenitor cells such that the hematopoietic stem cells retain their phenotype. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6030836 | | Application Number: | US1999000327840 | | Date Filed: | 08/06/1999 | | Date Published: | 29/02/2000 | | Assignee: | Osiris Therapeutics, Inc., Baltimore, MD, USA |
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