Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6030836

Title:Vitro maintenance of hematopoietic stem cells
Inventors:Thiede, Mark A.; Forest Hill, MD, USA
Pittenger, Mark F.; Severna Park, MD, USA
Mbalaviele, Gabriel; Columbia, MD, USA
Summary:Described herein are methods of maintaining human hematopoietic stem cells in vitro. The invention relates to human mesenchymal stem cells and human mesenchymal stem cell-derived adipocytes that have been isolated from a tissue specimen such as bone marrow cells, and which are then co-cultured with hematopoietic progenitor cells such that the hematopoietic stem cells retain their phenotype. Therapeutic applications in the treatment of hematopoietic disorders are included.
Abstract:The present invention is directed to human mesenchymal stem cells isolated from a tissue specimen, such as marrow cells, and to the method of co-culturing isolated mesenchymal stem cells and/or mesenchymal stem cell-derived adipocytes with hematopoietic progenitor cells such that the hematopoietic stem cells retain their phenotype.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6030836
Application Number:US1999000327840
Date Filed:08/06/1999
Date Published:29/02/2000
Assignee:Osiris Therapeutics, Inc., Baltimore, MD, USA


 
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