Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6043348

Title:Antibody recognizing a small subset of human hematopoietic cells
Inventors:Lawman, Michael J. P.; Gainesville, FL, USA
Lawman, Patricia; Gainesville, FL, USA
Summary:Described herein is a novel antibody specific for an antigen on a subset of primitive hematopoietic cells, methods and uses thereof. The invention relates to an antibody that has binding specificity for an antigen that is expressed on a subset of human, hematopoietic mononuclear cells, including a hematopoietic stem cell population, but is not expressed on normal, mature myeloid cells. Specific properties of the monoclonal antibody, MG1, are disclosed, as are methods by which it may be used in isolating cell suspensions from human blood and marrow. Therapeutic applications are included for the diagnosis and treatment of leukemia, for bone marrow reconstitution and for various uses in gene therapy.
Abstract:The subject invention pertains to antibodies that have binding specificity for an antigen that is expressed on a subset of human, hematopoietic mononuclear cells, including a hematopoietic stem cell population, but is not expressed on normal, mature myeloid cells. In one embodiment, a monoclonal antibody, MG1, is provided. This antibody is useful in methods of isolating cell suspensions from human blood and marrow that can be employed in bone marrow transplantation, genetic therapy, and in treating other diseases of the hematopoietic system. Cell suspensions containing MG1.sup.+ human hematopoietic cells are also provided, as well as therapeutic methods employing the cell suspensions. The subject invention also pertains to the novel antigen recognized by the subject antibodies.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6043348
Application Number:US1997000970032
Date Filed:13/11/1997
Date Published:28/03/2000
Assignee:None


 
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