Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6048964

Title:Compositions and therapeutic methods using morphogenic proteins and stimulatory factors
Inventors:Lee, John C.; San Antonio, TX, USA
Yeh, Lee-Chuan C.; San Antonio, TX, USA
Summary:Described herein are methods of improving tissue inductive activity of a bone morphogenic protein (BMP) on a mammalian progenitor cell. The invention relates to a process of coadministering a morphogenic protein stimulatory factor (MPSF) to a cell for improving the tissue inductive activity of morphogenic proteins belonging to the BMP protein family via the use of implantable morphogenic devices comprising a morphogenic protein and a MPSF disposed within a carrier. Claims of the invention include improved induction of tissue formation in allogeneic and xenogeneic implants, and an acceleration of allograft repair in a mammal using such morphogenic devices Further disclosed is a prosthetic device comprising a prosthesis coated with a morphogenic protein and a MPSF, and methods for promoting the in vivo integration of the implantable prosthetic device to enhance the bond strength between the prosthesis and the existing target tissue at the joining site. Therapeutic applications are included for the treatment of mammalian tissue degenerative conditions.
Abstract:
US Patent Website:Click Here for Full Text of Patent
Title Number:US6048964
Application Number:US1995000570752
Date Filed:12/12/1995
Date Published:11/04/2000
Assignee:Stryker Corporation, Kalamazoo, MI, USA


 
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