Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6048971

Title:Recombinant human erythropoietin mutants
Inventors:Sytkowski, Arthur J.; Arlington, MA, USA
Grodberg, Jennifer; Quebec, Canada
Summary:This invention introduces a secretable mutant human recombinant erythropoietin protein exhibiting enhanced biological activity. Further disclosed are properties of the DNA encoding the modified, secretable erythropoietin proteins, and methods for the production of such proteins. Claims of the invention include an improved capacity to regulate the growth and differentiation of red blood cell progenitors when compared to the wildtype recombinant erythropoietin. Specific amino acid residues are provided, as are therapeutic applications of such proteins in the diagnosis and treatment of anemia, erythroleukemias and other hematologic conditions.
Abstract:
US Patent Website:Click Here for Full Text of Patent
Title Number:US6048971
Application Number:US1997000808881
Date Filed:28/02/1997
Date Published:11/04/2000
Assignee:Beth Israel Deaconess Medical Center, Boston, MA, USA


 
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