Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6050990

Title:Methods and devices for inhibiting hair growth and related skin treatments
Inventors:Tankovich, Nikolai I.; San Diego, CA, USA
Dasse, Kurt A.; Needham, MA, USA
Fine, David H.; Lincoln, MA, USA
Fairchild, Paul W.; San Diego, CA, USA
Zhao, Zhong-Quan; San Diego, CA, USA
Lefebvre, Mike; San Diego, CA, USA
Lee, Jr., John; Ridgefield, CT, USA
Rolfe, Jonathan L.; North Easton, MA, USA
Murrell, SUSA
n; River Edge, NJ, USA
Hunter, II, Allen; San Diego, CA, USA
Reynolds, Amanda J; Richmond, United Kingdom
Kolinko, Vladimir G.; San Diego, CA, USA
Summary:Described herein are methods of inhibiting hair growth in combination with skin treatments. The invention relates to a process and apparatus for applying laser light to the skin for the removal of hair, or alternately for the stimulation and synchronization of hair growth. Disclosed herein are methods of controlling the proportions of photomechanical and photothermal damage by a selection of laser parameters, chromophore particle size and pulse duration with an optional dynamic skin cooling system while the hairs are in the anagen phase. Further disclosed are methods of grafting cloned hair stem cells into the hair ducts while administering methionine to a skin section to increase hair growth. Methods and materials are provided. Therapeutic applications are included for the treatment of herpes virus, for reducing sweat and body odor, for the in situ formation of chromophores in hair ducts, for reducing light loss at the skin surface, for the grafting of hair stem cells, and for removing keloid or hypertrophic scars.
Abstract:Methods of applying laser light to the skin, and apparatus therefor, include methods for removing hair, for synchronizing hair growth, for stimulating hair growth, for treating Herpes virus, for reducing sweat and body odor, for in situ formation of a chromophore in hair ducts, for reducing light loss at the skin surface, for grafting of hair stem cells, and for removing keloid or hypertrophic scars. The hair removal methods include controlling the proportions of photomechanical and photothermal damage by selection of laser parameters, chromophore particle size and/or pulse duration, with optional dynamic skin cooling. Additional hair removal methods include infiltrating a photoactivated drug into hair ducts and exposing the skin to sunlight or administering an anti-proliferative agent into hair ducts, for example, by encapsulating the anti-proliferative agent in a slow release vehicle. The methods of treating Herpes virus, reducing sweat or body odor, and removing keloid or hypertrophic scars include infiltrating a light-absorbing contaminant into hair ducts or other openings in the skin and illuminating the contaminated skin section. The methods for stimulating hair growth include grafting of cloned auto hair stem cells the hair ducts or administering methionine to a skin section to increase hair growth. Apparatus useful in performing these methods include devices for making a smooth optical boundary between skin and air or for dividing a light beam into a plurality of smaller light beams, and dressings for use before, during and after laser illumination.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6050990
Application Number:US1997000984892
Date Filed:04/12/1997
Date Published:18/04/2000
Assignee:ThermoLase Corporation, San Diego, CA, USA


 
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