Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6057123

Title:Stem cell inhibiting proteins
Inventors:Craig, Stewart; Oxford, United Kingdom
Hunter, Michael George; Buckinghamshire, United Kingdom
Edwards, Richard Mark; Oxford, United Kingdom
Czaplewski, Lloyd George; Oxford, United Kingdom
Gilbert, Richard James; Oxford, United Kingdom
Summary:Described herein are novel proteins with stem cell inhibition activity, methods and uses thereof. The invention relates to the proteinaceous molecule comprising an LD78 or MlP-1 ?a analogue and which contain mutations which prevent of reduce the formation of a stable multimer higher than a dodecamer. Claims of the invention include improved tissue penetration since aggregate formation is inhibited, and the resulting low molecular weight monomers or oligomers have improved solution properties which yield enhanced productivity. Therapeutic applications include use as protective agents of stem cells in the treatment of tumors.
Abstract:Proteinaceous molecules with stem cell inhibition activity are analogues of LD78 or MIP-1.alpha. which have mutations to prevent or reduce multimer formation beyond certain stages (for example a dodecamer). Aggregate formation is therefore inhibited, and the resulting low molecular weight monomers (or oligomers) have improved solution properties leading to enhanced productivity and greater therapeutic utility as stem cell protective agents, which are useful in tumour therapy.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6057123
Application Number:US1993000982759
Date Filed:08/03/1993
Date Published:02/05/2000
Assignee:British Biotech Pharmaceuticals Limited, Oxford, United Kingdom


 
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