Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6069010

Title:High throughput gene inactivation with large scale gene targeting
Inventors:Choi, Theodore Kyu; La Jolla, CA, USA
Summary:This invention introduces a recombinant-based method for increasing the efficiency of genomic targeting procedures in a cloned mammal. Described herein is a two-vector system which introduces vectors into a bacterial cell such that homologous recombination between the vectors occurs. Experimental applications are included for the generation of mutations in a recombination-based construction. Further provided are methods for incorporating such mutations into mouse embryonic stem cells and transgenic mice.
Abstract:The present invention provides a vector system that is useful for the generation of mutations in a recombination-based construction method. The invention further includes the incorporation of mutations generated by the method of the present invention into mouse embryonic stem cells and transgenic mice.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6069010
Application Number:US1996000711218
Date Filed:09/09/1996
Date Published:30/05/2000
Assignee:Axys Pharmaceuticals, Inc., South San Francisco, CA, USA


 
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