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Stem Cell Related Patent Number US6069010
| Title: | High throughput gene inactivation with large scale gene targeting | | Inventors: | Choi, Theodore Kyu; La Jolla, CA, USA | | Summary: | This invention introduces a recombinant-based method for increasing the efficiency of genomic targeting procedures in a cloned mammal. Described herein is a two-vector system which introduces vectors into a bacterial cell such that homologous recombination between the vectors occurs. Experimental applications are included for the generation of mutations in a recombination-based construction. Further provided are methods for incorporating such mutations into mouse embryonic stem cells and transgenic mice. | | Abstract: | The present invention provides a vector system that is useful for the generation of mutations in a recombination-based construction method. The invention further includes the incorporation of mutations generated by the method of the present invention into mouse embryonic stem cells and transgenic mice. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6069010 | | Application Number: | US1996000711218 | | Date Filed: | 09/09/1996 | | Date Published: | 30/05/2000 | | Assignee: | Axys Pharmaceuticals, Inc., South San Francisco, CA, USA |
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