Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6075124

Title:Human chemotactin protein
Inventors:Li, Haodong; Gaithersburg, MD, USA
Ruben, Steven M.; Olney, MD, USA
Sutton, III, Granger; Columbia, MD, USA
Summary:Described herein are novel human chemotactic polypeptides and the polynucleotides encoding the polypeptides. The invention relates to recombinant techniques for the production of such polypeptides as well as for their antagonists and the diagnostic assays which may be used in the identification of mutations in the nucleic acid sequences. Further disclosed are methods for recognizing altered levels of the polypeptide in the detection of disease. Therapeutic applications are included for stem cell mobilization, myeloprotection, neuronal protection, the treatment of tumors, the acceleration of wound healing, the treatment of parasitic infection, and the regulation of hematopoiesis.
Abstract:A human chemotactic polypeptide, DNA (RNA) encoding it, and a procedure for producing such a polypeptide by recombinant techniques are disclosed. Also disclosed are methods of using the polypeptide for a number of purposes, including: stem cell mobilization, myeloprotection, neuronal protection, treating tumors, wound healing, treating parasitic infection, and regulating hematopoiesis. Also disclosed are polypeptide antagonists and diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6075124
Application Number:US1998000044856
Date Filed:20/03/1998
Date Published:13/06/2000
Assignee:Human Genome Sciences, Inc., Rockville, MD, USA


 
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