Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6082364

Title:Pluripotential bone marrow cell line and methods of using the same
Inventors:Balian, Gary; Charlottesville, VA, USA
Wang, Gwo-Jaw; Charlottesville, VA, USA
Diduch, David; Charlottesville, VA, USA
Hahn, Chang; Charlottesville, VA, USA
Summary:This invention introduces a purified bone marrow preparation, methods and uses thereof. Described herein are pluripotent stem-like cells obtained from bone marrow which are capable of differentiating into osteocytes, chondrocytes and adipocytes, depending on the environmental conditions and treatment. Methods of administration to produce migration to bone marrow are provided, as are methods by which the cells may be transformed with recombinant DNA for the expression of both reporter genes and biological factors such as growth factors. Therapeutic applications are included for the treatment of osteoporosis, osteolysis, improved bone implantation adherence, and the augmentation of bone growth or bone and cartilage repair.
Abstract:Pluripotent stem-like cells obtained from bone marrow differentiate into osteocytes, chondrocytes and adipocytes, depending on the environment encountered and treatment. If systemically administered, the cells home, that is migrate, to bone marrow. The cells may be transformed with recombinant DNA for the expression of both reporter genes, and biological factors, such as growth factors. The cells may be systemically administered to treat osteoporosis, osteolysis, improve bone implant adherence, augment bone growth or bone repair, augment cartilage repair, augment fat production for, e.g., breast augmentation, and the like.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6082364
Application Number:US1997000990746
Date Filed:05/12/1997
Date Published:04/07/2000
Assignee:Musculoskeletal Development Enterprises, LLC, Charlottesville, VA, USA


 
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