Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6087113

Title:Monoclonal antibodies for human mesenchymal stem cells
Inventors:Caplan, Arnold I.; Cleveland Heights, OH, USA
Summary:Described herein are novel monoclonal antibodies for mesenchymal stem cells, methods and uses thereof. The invention relates to isolated human mesenchymal stem cells, their isolation, purification and expansion. Claims of the invention include monoclonal hybridoma cell lines (ATCC nos. 10743-10745) that synthesize and secrete these monospecific antibodies. Experimental, diagnostic and therapeutic applications are included.
Abstract:The invention relates to isolated human mesenchymal stem cells, a method for isolating, purifying, and culturally expanding human mesenchymal stem cells (i e. mesenchymal stem cells or MSCs), and characterization of (including by cytokine expression profiling) and uses, particularly research reagent, diagnostic and therapeutic uses for such cells. The stem cells can be culture expanded without differentiating. Further disclosed are monoclonal antibodies specific for human mesenchymal stem cells and the monoclonal hybridoma cell lines (ATCC nos. 10743-10745) that synthesize and secrete these monospecific antibodies, and uses of the monoclonal antibodies for diagnostic and/or therapeutic purposes.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6087113
Application Number:US1998000081913
Date Filed:19/05/1998
Date Published:11/07/2000
Assignee:Case Western Reserve University, Cleveland, OH, USA


 
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