Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6090365

Title:Radioimmunotherapy of lymphoma using anti-CD20 antibodies
Inventors:Kaminski, Mark S.; Ann Arbor, MI, USA
Butchko, Gregory M.; Miami Lakes, FL, USA
Glenn, Stephan D.; Davie, FL, USA
Wahl, Richard L.; Ann Arbor, MI, USA
Summary:Described herein are methods of radioimmunotherapy for lymphoma via the administration of a radioactively labeled anti-CD20 antibody. The invention relates specifically to the treatment of lymphoma with a B cell-specific antibody according to a process by which a patient receives both unlabeled antibodies and antibodies labeled with a radioisotope. Claims of the invention include therapeutic advantages by which this method elicits tumor responses which can be obtained in radiometric dosages and which do not require hematopoietic stem cell replacement as an adjuvant therapy.
Abstract:Methods for the treatment of lymphoma by administration of a B cell-specific antibody are described. The invention encompasses providing to a patient both unlabeled antibodies and antibodies labeled with a radioisotope. A principal advantage of the method is that tumor responses can be obtained in a radiometric dose range that does not require hematopoietic stem cell replacement as an adjunct therapy.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6090365
Application Number:US1997000972900
Date Filed:18/11/1997
Date Published:18/07/2000
Assignee:Coulter Pharmaceutical, Inc., South San Francisco, CA, USA Regents of the University of Michigan, Ann Arbor, MI, USA


 
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