Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6090782

Title:Hemoglobin alpha and beta chain peptide fragments useful for inhibiting stem cell proliferation
Inventors:Tsyrlova, Irena; Gaithersburg, MD, USA
Wolpe, Stephen D.; Rockville, MD, USA
Summary:Described herein are inhibitors of stem cell proliferation, methods and uses thereof. The invention relates to a process by which hemoglobin chains are utilized in the isolation and use of stem cell inhibiting factors which may then be used in the regulation of the abnormal stem cell cycle and for the acceleration of post-chemotherapy peripheral blood cell recovery. Specific amino acid sequences and their residues are disclosed. Therapeutic applications include the protection of mammalian stem cells from antiviral agents and for use in the treatment of cancer and in the maintenance of mammalian hematopoietic stem cells ex vivo.
Abstract:Disclosed and claimed are methods for the isolation and use of stem cell inhibiting factors for regulating the abnormal stem cell cycle and for accelerating the post-chemotherapy peripheral blood cell recovery. Also disclosed and claimed are the inhibitors of stem cell proliferation.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6090782
Application Number:US1998000005546
Date Filed:12/01/1998
Date Published:18/07/2000
Assignee:Pro-Neuron, Inc., Gaithersburg, MD, USA


 
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