Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6093531

Title:Generation of hematopoietic cells from multipotent neural stem cells
Inventors:Bjornson, Christopher R.; Seattle, WA, USA
Rietze, Rod L.; Brunswick, Australia
Reynolds, Brent A.; Saltspring, Canada
Vescovi, Angelo L.; Milan, Italy
Summary:Described herein are methods of generating hematopoietic cells from multipotent neural stem cells (MNSC) and their progeny. The invention relates to a process by which the MNSC progeny are placed in a hematopoietic-inducing environment which can be either ex vivo or in vivo, such as a mammal's circulatory system which can induce xenogeneic, allogeneic, or autologous MNSC progeny to generate a full complement of hematopoietic cells. Therapeutic applications include the use of MNSC progeny as an alternative to bone marrow and hematopoietic stem cell transplantation in the treatment of blood-related disorders.
Abstract:Multipotent neural stem cell (MNSC) progeny are induced to generate cells of the hematopoietic system by placing the MNSC progeny in a hematopoietic-inducing environment. The hematopoietic-inducing environment can be either ex vivo or in vivo. A mammal's circulatory system provides an in vivo environment that can induce xenogeneic, allogeneic, or autologous MNSC progeny to generate a full complement of hematopoietic cells. Transplantation of MNSC progeny provides an alternative to bone marrow and hematopoietic stem cell transplantation to treat blood-related disorders.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6093531
Application Number:US1998000100679
Date Filed:19/06/1998
Date Published:25/07/2000
Assignee:NeuroSpheres Holdings Ltd., Calgary, Canada


 
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