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Stem Cell Related Patent Number US6127135
| Title: | Methods of obtaining compositions enriched for hematopoietic stem cells, antibodies for use therein, compositions derived therefrom and methods of use thereof | | Inventors: | Hill, Beth Louise; Mountain View, CA, USA
Rozler, Elen; Mountain View, CA, USA
Chen, Benjamin P.; Fremont, CA, USA | | Summary: | Described herein are cellular compositions comprised of EM10 positive cells, methods and uses thereof. This invention relates to a novel ?aEM10 antibody which is specific for the unique EM10 cell marker, and a process by which the antibody may be used in determining hematopoietic stem cell content. Therapeutic applications are included for the isolation and assay of hematopoietic stem cells, and for the treatment of genetic diseases associated with hematopoietic cells such as sickle cell anaemia. | | Abstract: | This invention provides a novel antibody, designated the .alpha.EM10 antibody. Also provided are methods of determining hematopoietic stem cell content. The methods employ using antibodies (.alpha.EM10) specific for a unique cell marker (EM10) that is expressed on stem cells. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6127135 | | Application Number: | US1998000085193 | | Date Filed: | 27/05/1998 | | Date Published: | 03/10/2000 | | Assignee: | None |
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