Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6129911

Title:Liver stem cell
Inventors:Faris, Ronald A.; Providence, RI, USA
Summary:Described herein are novel isolated liver cell clusters of less than ten cells comprised of a liver stem cell and a hepatocyte. The invention relates to a primary liver stem cell and a cell doublet consisting of a hepatocyte and the stem cell, both of which are derived from normal liver tissue. Further disclosed are methods by which the cells are isolated and genetically altered and transplanted. Therapeutic applications in liver transplantation, gene therapy and in extracorporeal liver assistance devices are included.
Abstract:The invention provides a primary liver stem cell and a cell doublet consisting of a hepatocyte and the stem cell, both of which are derived from normal liver tissue. Methods of isolating the cells, genetically altering the cells, and using the cells for transplantation are also within the invention.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6129911
Application Number:US1998000113774
Date Filed:10/07/1998
Date Published:10/10/2000
Assignee:Rhode Island Hospital, A LifeSpan Partner, Providence, RI, USA


 
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