Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6130061

Title:Human stem cell antigen 2
Inventors:Ni, Jian; Rockville, MD, USA
Yu, Guo-Liang; Darnestown, MD, USA
Gentz, Reiner; Silver Spring, MD, USA
Gocayne, Jeannine D.; Potomac, MD, USA
Summary:Described herein are a novel human stem cell antigen 2 polypeptide and polynucleotide, methods and uses thereof. The invention relates to a human stem cell antigen 2 polypeptide and DNA (RNA) encoding the polypeptide, and a procedure for producing the polypeptide by recombinant techniques. Therapeutic applications include uses in gene therapy, in the stimulation of thymocyte maturation and differentiation, in the treatment of hyper-acute rejection, and in the treatment of Alzheimer's Disease and inflammation.
Abstract:A human stem cell antigen 2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for stimulating thymocyte maturation and differentiation, protecting neuronal cells, preventing rejection during organ transplantation, treating PNH, Alzheimer's Disease and inflammation is disclosed. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6130061
Application Number:US1996000746397
Date Filed:08/11/1996
Date Published:10/10/2000
Assignee:Human Genome Sciences, Inc., Rockville, MD, USA


 
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