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Stem Cell Related Patent Number US6130065
| Title: | Nitrobenzylmercaptopurineriboside (NBMPR)-insensitive, equilibrative, nucleoside transport protein, nucleic acids encoding the same and methods of use | | Inventors: | Belt, Judith A.; Memphis, TN, USA
Crawford, Charles R.; Memphis, TN, USA | | Summary: | Described herein is a novel nucleic acid encoding nucleoside transporter. The invention relates to an isolated NBMPR-insensitive equilibrative nucleoside transport protein (iENTP) and the nucleic acid encoding it. Therapeutic applications of the iENTP include uses in the screening of drugs and of assays for identifying natural nucleoside permeants or inhibitors and analogs thereof, and for the identification of antitumor and antiviral agents, and for uses in gene therapy. | | Abstract: | An isolated NBMPR-insensitive equilibrative nucleoside transport protein (iENTP) and the nucleic acid encoding it is disclosed. The iENTP can be used in screening assays to identify both natural nucleoside permeants and/or inhibitors and analogs thereof. In addition, transfected or transduced cell lines are disclosed which use the iENTP as the sole nucleoside transport protein. Methods of employing such cell lines for drug screening are also included. Furthermore methods of using hematopoietic stem cells transduced with an iENTP in a chemotherapy protocol is also described. In addition, methods of using these cells to selectively express a heterologous gene for gene therapy is disclosed. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6130065 | | Application Number: | US1998000058389 | | Date Filed: | 09/04/1998 | | Date Published: | 10/10/2000 | | Assignee: | St. Jude Children's Research Hospital, Memphis, TN, USA |
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