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| Title: | Retroviral gene therapy vectors and therapeutic methods based thereon |
| Inventors: | Riviere, Isabelle; Boston, MA, USA Cohen, Lawrence K.; Oakland, CA, USA Guild, Brad; Concord, MA, USA Rafield, Lori F.; San Francisco, CA, USA Robbins, Paul; Mt. Lebanon, PA, USA Mulligan, Richard C.; Lincoln, MA, USA |
| Summary: | This invention discloses retroviral vectors for gene therapy and relevant methods thereof. Such vectors include an insertion site for genes of interest and are capable of expressing high levels of the protein derived from the particular genes in a wide variety of transfected cell types. Also disclosed are retroviral vectors lacking a selectable marker, thus rendering them suitable for human gene therapy in the treatment of a variety of disease states without the co-expression of a marker product, such as an antibiotic. Recommendations for uses of such retroviral vectors, such as in packaging cell lines, are also provided. |
| Abstract: | Retroviral vectors are disclosed which include an insertion site for genes of interest and are capable of expressing high levels of the protein derived from the genes of interest in a wide variety of transfected cell types. Also disclosed are retroviral vectors lacking a selectable marker, thus rendering them suitable for human gene therapy in the treatment of a variety of disease states without the co-expression of a marker product, such as an antibiotic. These retroviral vectors are especially suited for use in certain packaging cell lines. |
| US Patent Website: | Click Here for Full Text of Patent |
| Title Number: | US6140111 |
| Application Number: | US1995000486858 |
| Date Filed: | 07/06/1995 |
| Date Published: | 31/10/2000 |
| Assignee: | Whitehead Institute for Biomedical Research, Cambridge, MA, USA |