Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6149902

Title:Manipulation of non-terminally differentiated cells using the notch pathway
Inventors:Artavanis-Tsakonas, Spyridon; Hamden, CT, USA
Fortini, Mark Edward; New Haven, CT, USA
Matsuno, Kenji; New Haven, CT, USA
Summary:Described herein are methods of expanding a human precursor cell using a Notch function agonist. The invention relates to methods for the expansion of non-terminally differentiated precursor cells by inhibiting the differentiation of the cells without inhibiting their proliferative mitotic activity by the use of this Notch function. Further disclosed are therapeutic applications in the production of non-differentiated cell populations for gene therapy and in the regeneration of tissue.
Abstract:The present invention is directed to methods for the expansion of non-terminally differentiated cells (precursor cells) using agonists of Notch function, by inhibiting the differentiation of the cells without inhibiting proliferation (mitotic activity) such that an expanded population of non-terminally differentiated cells is obtained. The cells are preferably stem or progenitor cells. These expanded cells can be used in cell replacement therapy to provide desired cell populations and help in the regeneration of diseased and/or injured tissues. The expanded cell populations can also be made recombinant and used for gene therapy, or can be used to supply functions associated with a particular precursor cell or its progeny cell.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6149902
Application Number:US1998000113825
Date Filed:10/07/1998
Date Published:21/11/2000
Assignee:Yale University, New Haven, CT, USA


 
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