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Stem Cell Related Patent Number US6153427
| Title: | Erythropoietin-inducible, erythroid-specific DNA construct | | Inventors: | King, Donna; Lake Bluff, IL, USA
Schneider, Gary B.; Gurnee, IL, USA | | Summary: | This invention describes an erythropoietin-inducible, erythroid-specific DNA construct consisting of a promoter sequence from a sheep juvenile beta globin gene, an erythroid-specific enhancer sequence from the locus control region of the human beta globin gene and a nucleotide coding sequence of interest. The enhancer sequence is described as comprising a DNase hypersensitive element from the locus control region of the human beta globin gene; and a nucleotide coding sequence operably linked to the promoter sequence. Specific properties are further disclosed. | | Abstract: | An erythropoietin-inducible, erythroid-specific DNA construct is disclosed. The DNA construct comprises a promoter sequence from a sheep juvenile beta globin gene, an erythroid-specific enhancer sequence from the locus control region of the human beta globin gene and a nucleotide coding sequence of interest. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6153427 | | Application Number: | US1994000321686 | | Date Filed: | 12/10/1994 | | Date Published: | 28/11/2000 | | Assignee: | Northeastern Ohio Universities College of Medicine, Rootstown, OH, USA |
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