Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6153427

Title:Erythropoietin-inducible, erythroid-specific DNA construct
Inventors:King, Donna; Lake Bluff, IL, USA
Schneider, Gary B.; Gurnee, IL, USA
Summary:This invention describes an erythropoietin-inducible, erythroid-specific DNA construct consisting of a promoter sequence from a sheep juvenile beta globin gene, an erythroid-specific enhancer sequence from the locus control region of the human beta globin gene and a nucleotide coding sequence of interest. The enhancer sequence is described as comprising a DNase hypersensitive element from the locus control region of the human beta globin gene; and a nucleotide coding sequence operably linked to the promoter sequence. Specific properties are further disclosed.
Abstract:An erythropoietin-inducible, erythroid-specific DNA construct is disclosed. The DNA construct comprises a promoter sequence from a sheep juvenile beta globin gene, an erythroid-specific enhancer sequence from the locus control region of the human beta globin gene and a nucleotide coding sequence of interest.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6153427
Application Number:US1994000321686
Date Filed:12/10/1994
Date Published:28/11/2000
Assignee:Northeastern Ohio Universities College of Medicine, Rootstown, OH, USA


 
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