Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6153441

Title:Methods of screening for agonists and antagonists for human CCR7 receptor and CK.beta.-9 ligand and interaction thereof
Inventors:Appelbaum, Edward R.; Blue Bell, PA, USA
Sarau, Henry M.; Harleysville, PA, USA
White, John R.; Coatesville, PA, USA
Summary:Described herein are methods of identifying agonists or antagonists of interaction between human protein chemokine beta-9 (CK?-9) and human CC chemokine receptor 7 (CCR7), via a process of contacting the cell-expressing receptor with a test compound. The invention relates to the agonists and antagonists of the interaction between CK?-9 and its cellular receptor, human CCR7, and methods of their identification and use. Therapeutic applications are included, such as in the treatment of allergic disorders, autoimmune diseases, ischemia or reperfusion injury, atherosclerosis, cancer, chronic inflammatory disorders, chronic rejection of transplanted organs or tissue grafts, chronic myelogenous leukemia, and infection by HIV and other pathogens.
Abstract:Disclosed are methods for discovering agonists and antagonists of the interaction between a secreted human protein, chemokine CK.beta.-9, and its cellular receptor, human CCR7, which may have utility in the treatment of several human diseases, including, but not limited to: allergic disorders, autoimmune diseases, ischemia/reperfusion injury, development of atherosclerotic plaques, cancer (including mobilization of hematopoietic stem cells for use in chemotherapy or mycloprotection during chemotherapy), chronic inflammatory disorders, chronic rejection of transplanted organs or tissue grafts, chronic myelogenous leukemia, and infection by HIV and other pathogens.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6153441
Application Number:US1999000251545
Date Filed:17/02/1999
Date Published:28/11/2000
Assignee:SmithKline Beecham Corporation, Philadelphia, PA, USA


 
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