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Stem Cell Related Patent Number US6159461
| Title: | Use of c-kit ligand with TNF-.alpha. and hematopoietic factors for the expansion or differentiation of hematopoietic cells | | Inventors: | Besmer, Peter; New York, NY, USA
Buck, Jochen; New York, NY, USA
Moore, Malcolm A. S.; New York, NY, USA
Nocka, Karl; Harvard, MA, USA | | Summary: | Described herein are compositions containing C-kit ligand and a hematopoietic factor as well as its antagonists and anti-sense nucleic acid. The invention relates to compositions comprising c-kit ligand, TNF-?a, and a hematopoietic factor and methods of their use in promoting the expansion and differentiation of peripheral blood or hematopoietic progenitor cells into dendritic cells. Therapeutic applications are included for the treatment of disorders such as leukemia, anaemia, AIDS, cancer, and allergies. | | Abstract: | Compositions comprising c-kit ligand, TNF-.alpha., and a hematopoietic factor are useful to promote the expansion of peripheral blood cells or the expansion and differentiation of hematopoietic progenitor cells. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6159461 | | Application Number: | US1997000898982 | | Date Filed: | 23/07/1997 | | Date Published: | 12/12/2000 | | Assignee: | Sloan-Kettering Institute for Cancer Research, New York, NY, USA |
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