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Stem Cell Related Patent Number US6159934
| Title: | Use of GHRH-RP to stimulate stem cell factor production | | Inventors: | Pescovitz, Ora H.; Carmel, IN, USA | | Summary: | Described herein is a growth hormone-releasing hormone related peptide, methods and uses thereof. The invention relates to novel uses of GHRH-RP polypeptides for activating Sertoli cell expression of stem cell factor and promoting spermatogenesis and fertility. Further disclosed are methods by which the GHRH-RP activity may be inhibited to decrease or eliminate spermatogenesis and fertility. Pharmaceutical compositions for such methods are provided, as are the transgenic animals lacking GHRH-RP expression of or expressing the newly introduced DNA encoding GHRH-RP polypeptides. | | Abstract: | Described are novel uses of GHRH-RP polypeptides for specifically activating Sertoli cell expression of stem cell factor and promoting spermatogenesis and fertility, and for inhibiting GHRH-RP activity to decrease or eliminate spermatogenesis and fertility. Also described are pharmaceutical compositions for such uses, and transgenic animals lacking expression of or expressing introduced DNA encoding GHRH-RP polypeptides. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6159934 | | Application Number: | US1996000777708 | | Date Filed: | 20/12/1996 | | Date Published: | 12/12/2000 | | Assignee: | Indiana University Foundation, Bloomington, IN, USA |
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