Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6159934

Title:Use of GHRH-RP to stimulate stem cell factor production
Inventors:Pescovitz, Ora H.; Carmel, IN, USA
Summary:Described herein is a growth hormone-releasing hormone related peptide, methods and uses thereof. The invention relates to novel uses of GHRH-RP polypeptides for activating Sertoli cell expression of stem cell factor and promoting spermatogenesis and fertility. Further disclosed are methods by which the GHRH-RP activity may be inhibited to decrease or eliminate spermatogenesis and fertility. Pharmaceutical compositions for such methods are provided, as are the transgenic animals lacking GHRH-RP expression of or expressing the newly introduced DNA encoding GHRH-RP polypeptides.
Abstract:Described are novel uses of GHRH-RP polypeptides for specifically activating Sertoli cell expression of stem cell factor and promoting spermatogenesis and fertility, and for inhibiting GHRH-RP activity to decrease or eliminate spermatogenesis and fertility. Also described are pharmaceutical compositions for such uses, and transgenic animals lacking expression of or expressing introduced DNA encoding GHRH-RP polypeptides.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6159934
Application Number:US1996000777708
Date Filed:20/12/1996
Date Published:12/12/2000
Assignee:Indiana University Foundation, Bloomington, IN, USA


 
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