Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6162427

Title:Combination of G-CSF with a chemotherapeutic agent for stem cell mobilization
Inventors:Baumann, Matthias; Karl-Ludwig-Strasse, Germany
Ochlich, Peter-Paul; Wallonenstrasse, Germany
Summary:Described herein is a granulocyte colony stimulating factor (G-CSF) and chemotherapeutic agents, methods and uses thereof. The invention introduces a G-CSF in combination with a chemotherapeutic agent such as cyclophosphamide and methods of producing a pharmaceutical preparation thereof. Further disclosed are techniques by which such a pharmaceutical preparation may be used to boost the mobilization of hematopoietic stem cells from bone marrow in the therapeutic treatment of diseases requiring peripheral stem cell transplantation, thereby resulting in increased efficiency of leukapheresis before myeloblative or myelotoxic therapy.
Abstract:The invention relates to the use of G-CSF in combination with a chemotherapeutic agent (in particular, cyclophosphamide) to produce a pharmaceutical preparation for boosting the mobilization of hematopoietic stem cells from bone marrow in the treatment of diseases requiring peripheral stem cell transplantation. The claimed combination results in more efficient leukapheresis, e.g. before myeloblative or myelotoxic therapy.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6162427
Application Number:US1998000091401
Date Filed:12/11/1998
Date Published:19/12/2000
Assignee:Roche Diagnostics GmbH, Mannheim, Germany


 
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