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Stem Cell Related Patent Number US6162427
| Title: | Combination of G-CSF with a chemotherapeutic agent for stem cell mobilization | | Inventors: | Baumann, Matthias; Karl-Ludwig-Strasse, Germany
Ochlich, Peter-Paul; Wallonenstrasse, Germany | | Summary: | Described herein is a granulocyte colony stimulating factor (G-CSF) and chemotherapeutic agents, methods and uses thereof. The invention introduces a G-CSF in combination with a chemotherapeutic agent such as cyclophosphamide and methods of producing a pharmaceutical preparation thereof. Further disclosed are techniques by which such a pharmaceutical preparation may be used to boost the mobilization of hematopoietic stem cells from bone marrow in the therapeutic treatment of diseases requiring peripheral stem cell transplantation, thereby resulting in increased efficiency of leukapheresis before myeloblative or myelotoxic therapy. | | Abstract: | The invention relates to the use of G-CSF in combination with a chemotherapeutic agent (in particular, cyclophosphamide) to produce a pharmaceutical preparation for boosting the mobilization of hematopoietic stem cells from bone marrow in the treatment of diseases requiring peripheral stem cell transplantation. The claimed combination results in more efficient leukapheresis, e.g. before myeloblative or myelotoxic therapy. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6162427 | | Application Number: | US1998000091401 | | Date Filed: | 12/11/1998 | | Date Published: | 19/12/2000 | | Assignee: | Roche Diagnostics GmbH, Mannheim, Germany |
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