Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6165785

Title:Bone marrow cultures for developing suppressor and stimulator cells for research and therapeutic applications
Inventors:Ogle, Cora K.; Cincinnatti, OH, USA
Valente, John F.; Cincinnatti, OH, USA
Alexander, J. Wesley; Cincinnatti, OH, USA
Summary:Described herein are methods of producing an immune system suppressor and cell stimulator. The invention relates to a therapeutic process incorporating immune system suppressor cells and immune system stimulator cells from a combination of stem cells and lymphoid-derived cells to which a lipopolysaccharide is added as well as a factor selected from the group consisting of a granulocyte macrophage-colony stimulating factor, a macrophage colony stimulating factor, and a granulocyte-colony stimulating factor. Methods of administering such immune system suppressor and stimulator cells from the co-culture into a host are provided. Therapeutic applications are included, such as in the promotion of allograft survival via the co-culturing of stems cells with lymphoid-derived cells.
Abstract:A method of treatment using immune system suppressor cells and immune system stimulator cells comprises providing stem cells; combining the stem cells with lymphoid-derived cells to produce a co-culture; adding lipopolysaccharide and a factor selected from the group consisting of granulocyte macrophage-colony stimulating factor, macrophage colony stimulating factor, granulocyte-colony stimulating factor and mixtures thereof to the co-culture; obtaining immune system suppressor cells and immune system stimulator cells from the co-culture; and introducing and the cells into a host.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6165785
Application Number:US1998000178045
Date Filed:23/10/1998
Date Published:26/12/2000
Assignee:University of Cincinnati, Cincinnati, OH, USA Shriners Hospitals for Children, Tampa, FL, USA


 
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