|
|
|
Stem Cell Related Patent Number US6165785
| Title: | Bone marrow cultures for developing suppressor and stimulator cells for research and therapeutic applications | | Inventors: | Ogle, Cora K.; Cincinnatti, OH, USA
Valente, John F.; Cincinnatti, OH, USA
Alexander, J. Wesley; Cincinnatti, OH, USA | | Summary: | Described herein are methods of producing an immune system suppressor and cell stimulator. The invention relates to a therapeutic process incorporating immune system suppressor cells and immune system stimulator cells from a combination of stem cells and lymphoid-derived cells to which a lipopolysaccharide is added as well as a factor selected from the group consisting of a granulocyte macrophage-colony stimulating factor, a macrophage colony stimulating factor, and a granulocyte-colony stimulating factor. Methods of administering such immune system suppressor and stimulator cells from the co-culture into a host are provided. Therapeutic applications are included, such as in the promotion of allograft survival via the co-culturing of stems cells with lymphoid-derived cells. | | Abstract: | A method of treatment using immune system suppressor cells and immune system stimulator cells comprises providing stem cells; combining the stem cells with lymphoid-derived cells to produce a co-culture; adding lipopolysaccharide and a factor selected from the group consisting of granulocyte macrophage-colony stimulating factor, macrophage colony stimulating factor, granulocyte-colony stimulating factor and mixtures thereof to the co-culture; obtaining immune system suppressor cells and immune system stimulator cells from the co-culture; and introducing and the cells into a host. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6165785 | | Application Number: | US1998000178045 | | Date Filed: | 23/10/1998 | | Date Published: | 26/12/2000 | | Assignee: | University of Cincinnati, Cincinnati, OH, USA
Shriners Hospitals for Children, Tampa, FL, USA |
|
|
