Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6171610

Title:Guided development and support of hydrogel-cell compositions
Inventors:Vacanti, Charles A.; Uxbridge, MA, USA
Vacanti, Joseph P.; Winchester, MA, USA
Vacanti, Martin P.; Westborough, MA, USA
Summary:Described herein are methods of generating new tissue via a liquid hydrogel-cell composition which includes a hydrogel with tissue precursor cells. Further disclosed are methods by which the liquid hydrogel-cell composition is delivered into a permeable, biocompatible support structure and allowed to solidify, wherein the tissue precursor cells are also allowed to grow and generate new tissue. Claims of the invention include a tissue-forming structure including a permeable, biocompatible support structure having a predetermined shape that corresponds to the shape of the desired tissue. Therapeutic applications in the treatment of bone, cartilage, nervous tissue and autonomic nervous system defects are provided.
Abstract:The invention features a method for generating new tissue by obtaining a liquid hydrogel-cell composition including a hydrogel and tissue precursor cells; delivering the liquid hydrogel-cell composition into a permeable, biocompatible support structure; and allowing the liquid hydrogel-cell composition to solidify within the support structure and the tissue precursor cells to grow and generate new tissue. The invention also features a tissue forming structure including a permeable, biocompatible support structure having a predetermined shape that corresponds to the shape of desired tissue; and a hydrogel-cell composition at least partially filling the support structure, wherein the hydrogel-cell composition includes a hydrogel and tissue precursor cells. The new tissue forming structure can be used in new methods to generate various tissues (e.g., to treat defective tissue) including new bone, cartilage, and nervous tissue such as spinal cord tissue. The invention also new isolated nervous system stem cells.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6171610
Application Number:US1998000200033
Date Filed:25/11/1998
Date Published:09/01/2001
Assignee:University of Massachusetts, Boston, MA, USA The Children's Medical Center Corporation, Boston, MA, USA


 
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