Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6174333

Title:Biomatrix for soft tissue regeneration using mesenchymal stem cells
Inventors:Kadiyala, Sudhakar; Baltimore, MD, USA
Caplan, Arnold I.; Cleveland Heights, OH, USA
Fink, David J.; Shaker Heights, OH, USA
Young, Randall G.; Ellicott City, MD, USA
Summary:Described herein is an implant for the repair of mammalian tissue defects. The invention relates to a contracted gel matrix formed in a planar mat with a plurality of physiologically compatible load-bearing sutures for securing tissue under tension adjacent to the defect to be repaired. Further disclosed are properties of the sutures for supporting a tissue reparative cell mass in the defect such that the sutures have a central portion encapsulated in a cell-containing matrix which is contracted under a tensile load by the cells and formed into a mat sheet during the contraction to which spring metal wires hold the sutures under tension during the contraction. The matrix is described as being a collagen gel or other material which the cells contract, with the cells constituting human mesenchymal stem cells. Also provided are methods by which the mat sheet is rolled into a spiral roll with the sutures extending from opposite roll ends to form the desired implant. Multiple embodiments of the invention are provided.
Abstract:An implant for repair of a tissue defect comprises a plurality of physiologically compatible load-bearing sutures for securing under tension tissue adjacent to the defect to be repaired, the sutures for supporting a tissue reparative cell mass in the defect and a tissue reparative cell mass supported thereby. The sutures have a central portion encapsulated in a cell containing matrix which is contracted under a tensile load by the cells thereof and formed into a mat sheet during the contraction. Spring metal wires hold the sutures in tension during the contraction. The matrix is a collagen gel or other material which the cells contract, the cells comprising human mesenchymal stem cells. The mat sheet is then rolled into a spiral roll with the sutures extending from opposite roll ends to form the desired implant. Different embodiments are disclosed.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6174333
Application Number:US1998000222688
Date Filed:29/12/1998
Date Published:16/01/2001
Assignee:Osiris Therapeutics, Inc., Baltimore, MD, USA


 
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