Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6207454

Title:Method for enhancing the effciency of gene transfer with stem cell factor (SCF) polypeptide
Inventors:Zsebo, Krisztina M.; Thousand Oaks, CA, USA
Bosselman, Robert A.; Thousand Oaks, CA, USA
Suggs, Sidney V.; Newbury Park, CA, USA
Martin, Francis H.; Thousand Oaks, CA, USA
Summary:Described herein are methods of enhancing the efficiency of transfer of a polynucleotide into a target mammalian cell in vitro, via a process of exposing the cell that expresses a stem cell factor receptor to a stem cell factor, and introducing a polynucleotide into the cell in vitro. Therapeutic applications in the treatment of blood disorders are included. This invention represents a continuation of other applications filed by the same assignee and inventors.
Abstract:Novel stem cell factors, oligonucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders involving blood cells are also disclosed.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6207454
Application Number:US1998000224681
Date Filed:31/12/1998
Date Published:27/03/2001
Assignee:Amgen Inc., Thousand Oaks, CA, USA


 
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