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Stem Cell Related Patent Number US6210574
| Title: | System for separation of nucleated fetal erythrocytes from maternal blood samples | | Inventors: | Sammons, David W.; Tucson, AZ, USA
Twitty, Garland E.; Tucson, AZ, USA
Utermohlen, Joseph G.; Tucson, AZ, USA
Sharnez, Rizwan; Sicklerville, NJ, USA | | Summary: | Described herein is a system of recovery of rare nucleated cells, especially fetal blood cells, via the use of a novel gravity biased, counterflow stabilized electrophoretic separator. The invention relates to methods for separating nucleated cells from a blood sample via a charge-flow separator (CFS) which separates blood into fractions according to the surface charge density characteristics, and which is coupled with an affinity-filtration separator which either outputs a separated blood fraction to the CFS or receives a separated blood fraction from the CFS. Further claims of the invention include the separation of nucleated fetal red blood cells, erythroid progenitor cells and other nucleated cells found in blood samples. Therapeutic applications in the prenatal screening of genetic diseases are included. | | Abstract: | A system for separating nucleated cells from a blood sample includes a charge-flow separator (CFS), which separates blood into fractions according to the surface charge density characteristics coupled with an affinity-filtration separator which either outputs a separated blood fraction to the CFS or receives a separated blood fraction from the CFS. The system permits separation of nucleated fetal red blood cells, erythroid progenitor cells and other nucleated cells found in blood samples. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6210574 | | Application Number: | US1999000317374 | | Date Filed: | 24/05/1999 | | Date Published: | 03/04/2001 | | Assignee: | BioSeparations, Inc., Tucson, AZ, USA |
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