Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6210668

Title:Destruction of contaminating tumor cells in stem cell transplants using bispecific antibodies
Inventors:Lindhofer, Horst; Grobenzell, Germany
Menzel, Helge; Munchen, Germany
Kolb, Hans-Jochem; Munchen, Germany
Thierfelder, Stefan; Eichenau, Germany
Summary:Described herein are methods of destruction of tumor cells in stem cell grafts via the use of a bi-specific antibody comprised of intact antibodies. The invention relates to a procedure for the destruction of contaminating tumor cells in stem cell transplants ex vivo using intact bispecific antibodies capable of binding to the T cell receptor complex of a T cell, to tumor-associated antigens on a tumor cell, and to Fc-receptors of accessory cells via the Fc part of the antibody, under specific conditions. Methods of preparation, redirection, destruction and reinfusion are disclosed. Therapeutic applications in the treatment of patients suffering from cancer are included.
Abstract:The present invention discloses a procedure for the destruction of contaminating tumor cells in stem cell transplants ex vivo using intact bispecific antibodies.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6210668
Application Number:US1999000422878
Date Filed:21/10/1999
Date Published:03/04/2001
Assignee:GSF Forschungszentrum fur Umwelt und Gesundheit GmbH, Oberschleissheim, Germany


 
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