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Stem Cell Related Patent Number US6218186
| Title: | HIV-MSCV hybrid viral vector for gene transfer | | Inventors: | Choi, John Kim; Boothwyn, PA, USA
Gewirtz, Alan M.; Narberth, PA, USA | | Summary: | This invention describes a hybrid viral vector for the transfer of selected genes to cells and mammals, such that the vector is a hybrid of a human immunodeficiency-based lentivirus and a murine stem cell retrovirus. Introduced herein is a hybrid viral vector comprising a human immunodeficiency virus and a murine stem cell retrovirus wherein the 3' long terminal repeat of the lentivirus is replaced by a modified 3' long terminal repeat comprising 50 base pairs of a 5', end of the human immunodeficiency virus U3 region, a complete murine stem cell retrovirus long terminal repeat, and 50 base pairs of a 3' end of the human immunodeficiency virus U3 region followed by a complete human immunodeficiency virus RU5 region, which are described as being operably linked in that order. | | Abstract: | A hybrid viral vector for transfer of selected genes to cells and mammals is provided. The vector is a hybrid of human immunodeficiency-based lentivirus and murine stem cell retrovirus. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6218186 | | Application Number: | US1999000439000 | | Date Filed: | 12/11/1999 | | Date Published: | 17/04/2001 | | Assignee: | Trustees of the University of Pennsylvania, Philadelphia, PA, USA |
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