Methods comprising apoptosis inhibitors for the generation of transgenic pigs

Stem Cell Clinic
Patient Application
FAQ
Contact
Locations
News
Videos
Research
Patents
3D Culture/Scaffold
Administration
Differentiation
Expansion
Extraction/Preservation
Mobilization
Type
USE
 


Stem Cell Related Patent Number US6218186

Title:HIV-MSCV hybrid viral vector for gene transfer
Inventors:Choi, John Kim; Boothwyn, PA, USA
Gewirtz, Alan M.; Narberth, PA, USA
Summary:This invention describes a hybrid viral vector for the transfer of selected genes to cells and mammals, such that the vector is a hybrid of a human immunodeficiency-based lentivirus and a murine stem cell retrovirus. Introduced herein is a hybrid viral vector comprising a human immunodeficiency virus and a murine stem cell retrovirus wherein the 3' long terminal repeat of the lentivirus is replaced by a modified 3' long terminal repeat comprising 50 base pairs of a 5', end of the human immunodeficiency virus U3 region, a complete murine stem cell retrovirus long terminal repeat, and 50 base pairs of a 3' end of the human immunodeficiency virus U3 region followed by a complete human immunodeficiency virus RU5 region, which are described as being operably linked in that order.
Abstract:A hybrid viral vector for transfer of selected genes to cells and mammals is provided. The vector is a hybrid of human immunodeficiency-based lentivirus and murine stem cell retrovirus.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6218186
Application Number:US1999000439000
Date Filed:12/11/1999
Date Published:17/04/2001
Assignee:Trustees of the University of Pennsylvania, Philadelphia, PA, USA


 
Copyright © 2007 The Institute for Cellular Medicine  8/5/2020