Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6221359

Title:Hemopoietic stem cell multiplier
Inventors:Komiyama, Atsushi; Matsumoto, Japan
Nakahata, Tatsutoshi; Matsumoto, Japan
Kubo, Tetsuo; Matsumoto, Japan
Tanaka, Ryuhei; Tsu, Japan
Kawano, Genji; Kamakura, Japan
Sudo, Tetsuo; Kamakura, Japan
Sano, Emiko; Yokohama, Japan
Kojima, Katsuaki; Yokohama, Japan
Summary:Described herein is a hematopoietic stem cell multiplier comprised of IL-3 and IL-7, methods and uses thereof. The invention relates to a hemopoietic stem cell augmenting agent in which at least one type of hepatocyte growth factor is contained as an active component, such that the hepatocyte growth factor is derived from human normal fibroblasts and may be obtained by genetic recombination techniques. Claims of the invention include an augmenting activity which the hepatocyte growth factor has on undifferentiated pluripotent hemopoietic stem cells, such that the growth factor may be used as a hemopoietic stem cell augmenting agent in the therapeutic treatment of bone marrow suppression, for the treatment of bone marrow disorders and for the in vitro growth of peripheral blood stem cells and bone marrow stem cells.
Abstract:A hemopoietic stem cell augmenting agent in which at least one type of hepatocyte growth factor is contained as an active component is provided. The hepatocyte growth factor has an augmenting activity on undifferentiated pluripotent hemopoietic stem cells and is useful as a hemopoietic stem cell augmenting agent for treatment of bone marrow suppression and for treatment of bone marrow malfunctions and furthermore is useful for in vitro growth of peripheral blood stem cells and bone marrow stem cells. Furthermore, a hepatocyte growth factor derived from human normal fibroblasts which is considered to be a type of hepatocyte growth factor can be obtained by genetic recombination techniques, and said factor is also useful as a hemopoietic stem cells augmenting agent.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6221359
Application Number:US1993000030410
Date Filed:21/05/1993
Date Published:24/04/2001
Assignee:Toray Industries, Inc., Tokyo, Japan


 
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