Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6225051

Title:Method of detecting solid cancer cells and tissue atypia and method of testing tissues for use in bone marrow transplantation and peripheral blood stem cell transplantation
Inventors:Sugiyama, Haruo; Mino-shi, Osaka 562, Japan
Inoue, Kazushi; Ibaraki, Japan
Summary:This invention describes the detection of solid tumor cells in tissue via a process of measuring the WT1 gene expression level. Described herein is a method of detecting the atypia of a tissue and a method of testing a graft material tissue for bone marrow or peripheral blood stem cell transplantation by determining the level of expression of the WT1 gene in a CD34- cell fraction of the tissue to detect leukemic cells and solid cancer cells in the tissue. Therapeutic applications are included, such as in the examination of bone marrow and peripheral blood stem cells prior to use in transplantation.
Abstract:The invention provides a method of detecting solid cancer cells which comprises determining the level of expression of WT1 gene in a test tissue, a method of detecting the atypia of a tissue which comprises determining the level of expression of WT1 gene in the tissue, and a method of testing a graft material tissue for bone marrow or peripheral blood stem cell transplantation which comprises determining the level of expression of WT1 gene in a CD34.sup.- cell fraction of the tissue to detect leukemic cells and solid cancer cells in the tissue.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6225051
Application Number:US1998000973967
Date Filed:26/06/1998
Date Published:01/05/2001
Assignee:Sugiyama; Haruo, Osaka, Japan Kishimoto; Tadamitsu, Osaka, Japan


 
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