Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6225119

Title:Production of megakaryocytes by the use of human mesenchymal stem cells
Inventors:Qasba, Pankaj; Columbia, MD, USA
Thiede, Mark A.; Forest Hill, MD, USA
Summary:Described herein are in vitro methods of production of megakaryocytes via the isolation of hematopoietic progenitor cells from a tissue specimen, such as marrow cells or peripheral blood, which are then co-cultured with human mesenchymal stem cells to induce megakaryocyte differentiation and platelet production. Further disclosed are methods by which the hematopoietic stem cells may be genetically engineered to carry genes of interest, particularly for the expression of physiologically active proteins. Therapeutic applications include the treatment of blood disorders and the acceleration of wound healing.
Abstract:The present invention is directed to hematopoietic progenitor cells isolated from a tissue specimen, such as marrow cells or peripheral blood, and to the method of co-culturing isolated hematopoietic progenitor cells with human mesenchymal stem cells to induce megakaryocyte differentiation and platelet production. In addition, hematopoietic stem cells can be genetically engineered to carry genes of interest particularly for the expression of physiologically active proteins. In the presence of mesenchymal stem cells, the transduced cells carry the new genetic material and express gene products that can be used to modulate blood disorders.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6225119
Application Number:US1999000316797
Date Filed:21/05/1999
Date Published:01/05/2001
Assignee:Osiris Therapeutics, Inc., Baltimore, MD, USA


 
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