Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6235527

Title:Lineage restricted glial precursors from the central nervous system
Inventors:Rao, Mahendra S.; Salt Lake City, UT, USA
Noble, Mark; Sandy, UT, USA
Mayer-Proschel, Margot; Sandy, UT, USA
Summary:This invention describes a population of mammalian central nervous system glial restricted precursor cells, methods and uses thereof. Described herein are A2B5+ E-NCAM- glial-restricted precursor (GRP) cells capable of differentiating into oligodendrocytes, A2B5+ process-bearing astrocytes, and A2B5- fibroblast-like astrocytes, but not into neurons. Also provided are methods by which GRP cells may be maintained by regeneration in culture. The GRP cells are described as differing from oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells in growth factor requirements, morphology, and progeny.
Abstract:A glial precursor cell population from mammalian central nervous system has been isolated. These A2B5.sup.+ E-NCAM.sup.- glial-restricted precursor (GRP) cells are capable of differentiating into oligodendrocytes, A2B5.sup.+ process-bearing astrocytes, and A2B5.sup.- fibroblast-like astrocytes, but not into neurons. GRP cells can be maintained by regeneration in culture. GRP cells differ from oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells in growth factor requirements, morphology, and progeny. Methods of use of GRP cells are also disclosed.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6235527
Application Number:US1997000980850
Date Filed:29/11/1997
Date Published:22/05/2001
Assignee:University of Utah Research Foundation, Salt Lake City, UT, USA


 
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