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Stem Cell Related Patent Number US6238902
| Title: | Protein tyrosine phosphatases | | Inventors: | Cheng, Jill; Burlingame, CA, USA
Lasky, Laurence A.; SaUSA
lito, CA, USA | | Summary: | Described herein is an isolated non-receptor protein tyrosine phosphatase of hematopoietic stem cells (PTP HSC), methods and uses thereof. The invention relates to a process by which such phosphatases are useful for the expansion of undifferentiated stem cells in cell culture. Specifically addressed herein are the native murine and human PTP HSCs, their analogs in other mammals, their functional derivatives, the nucleic acids encoding these proteins, the vectors containing and expressing such nucleic acids, and the recombinant host cells that are transformed by the nucleic acids. Also provided are assays for identifying agonists and antagonists of the native PTP HSCs, methods for the expansion of undifferentiated stem cells, and methods for the induction of stem cell differentiation. | | Abstract: | This invention concerns new non-receptor protein tyrosine phosphatases of the hematopoietic stem cells (PTP HSC). The invention specifically concerns native murine and human PTP HSCs, their analogs in other mammals, and their functional derivatives. The invention further relates to nucleic acid encoding these proteins, vectors containing and capable of expressing such nucleic acid, and recombinant host cells transformed with such nucleic acid. Assays for identifying agonists and antagonists of the native PTP HSCs, methods for expansion of undifferentiated stem cells, and methods for the induction of stem cell differentiation are also within the scope of the invention. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6238902 | | Application Number: | US1997000821278 | | Date Filed: | 20/03/1997 | | Date Published: | 29/05/2001 | | Assignee: | Genentech, Inc., South San Francisco, CA, USA |
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