Methods comprising apoptosis inhibitors for the generation of transgenic pigs

Stem Cell Clinic
Patient Application
FAQ
Contact
Locations
News
Videos
Research
Patents
3D Culture/Scaffold
Administration
Differentiation
Expansion
Extraction/Preservation
Mobilization
Type
USE
 


Stem Cell Related Patent Number US6238902

Title:Protein tyrosine phosphatases
Inventors:Cheng, Jill; Burlingame, CA, USA
Lasky, Laurence A.; SaUSA
lito, CA, USA
Summary:Described herein is an isolated non-receptor protein tyrosine phosphatase of hematopoietic stem cells (PTP HSC), methods and uses thereof. The invention relates to a process by which such phosphatases are useful for the expansion of undifferentiated stem cells in cell culture. Specifically addressed herein are the native murine and human PTP HSCs, their analogs in other mammals, their functional derivatives, the nucleic acids encoding these proteins, the vectors containing and expressing such nucleic acids, and the recombinant host cells that are transformed by the nucleic acids. Also provided are assays for identifying agonists and antagonists of the native PTP HSCs, methods for the expansion of undifferentiated stem cells, and methods for the induction of stem cell differentiation.
Abstract:This invention concerns new non-receptor protein tyrosine phosphatases of the hematopoietic stem cells (PTP HSC). The invention specifically concerns native murine and human PTP HSCs, their analogs in other mammals, and their functional derivatives. The invention further relates to nucleic acid encoding these proteins, vectors containing and capable of expressing such nucleic acid, and recombinant host cells transformed with such nucleic acid. Assays for identifying agonists and antagonists of the native PTP HSCs, methods for expansion of undifferentiated stem cells, and methods for the induction of stem cell differentiation are also within the scope of the invention.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6238902
Application Number:US1997000821278
Date Filed:20/03/1997
Date Published:29/05/2001
Assignee:Genentech, Inc., South San Francisco, CA, USA


 
Copyright © 2007 The Institute for Cellular Medicine  6/22/2021