Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6242579

Title:Antigen found on a small subset of human hematopoietic cells which binds to monoclonal antibody MG1
Inventors:Lawman, Michael J. P.; Key Largo, FL, USA
Lawman, Patricia; Key Largo, FL, USA
Summary:This invention introduces a novel antibody specific for an antigen on a subset of primitive hematopoietic cells, methods and uses thereof. Described herein is an antigen that is expressed on a subset of human, hematopoietic mononuclear cells, including a hematopoietic stem cell population, but is not expressed on normal, mature myeloid cells and which binds to the monoclonal antibody MG1. Claims of the invention include uses of the antibody in the isolation of cell suspensions from human blood and marrow, wherein such cell suspensions are known to contain MG1+ human hematopoietic cells. Therapeutic applications include uses in bone marrow transplantation, gene therapy, and in the treatment of leukemia and other diseases of the hematopoietic system.
Abstract:The subject invention pertains to an antigen that is expressed on a subset of human, hematopoietic mononuclear cells, including a hematopoietic stem cell population, but is not expressed on normal, mature myeloid cells and binds to monoclonal antibody MG1. This antibody is useful in methods of isolating cell suspensions from human blood and marrow that can be employed in bone marrow transplantation, genetic therapy, and in treating other diseases of the hematopoietic system. Cell suspensions containing MG1.sup.+ human hematopoietic cells are also provided, as well as therapeutic methods employing the cell suspensions. The subject invention also pertains to the novel antigen recognized by the subject antibodies.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6242579
Application Number:US2000000531827
Date Filed:21/03/2000
Date Published:05/06/2001
Assignee:None


 
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