Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6245810

Title:Amino acid derivatives
Inventors:Ishizuka, Masaaki; Mishima, Japan
Kawazu, Masaji; Numazu, Japan
Katsumi, Toshiaki; Himeji, Japan
Fuse, Yoshihide; Himeji, Japan
Maeda, Kenji; Tokyo, Japan
Takeuchi, Tomio; Tokyo, Japan
Summary:Described herein are novel T-cell growth promoting amino acid derivatives such as immunomodulatory and anticancer agents and hematopoietic stem cell growth promoters. The invention relates to a novel amino acid derivative or a salt thereof and methods of their production via chemical synthesis. Claims of the invention include the ability of these new compounds to stimulate proliferation and physiological activities of T cells of mammals, as well as the ability to exhibit an immunomodulating activity as well as an antitumor activity or a carcinostatic activity. Further described is the property of these new compounds to stimulate the proliferation of hematopoietic stem cells. Precise sequences, formulae and chemical configurations are disclosed.
Abstract:A novel amino acid derivative represented by the general formula (I) shown below or a salt thereof have now been provided by chemical synthesis, and it has been found that these new compounds stimulate proliferation and physiological activities of the T cells of mammals, have an immunomodulating activity and also have an antitumor activity or a carcinostatic activity. It has also been found that these new compounds have an effect of stimulating the proliferation of hematopoietic stem cells. ##STR1## wherein y is 0 or 1; R.sup.1 represents an unsubstituted C.sub.1 -C.sub.8 alkyl group or others; R.sup.2 represents a hydrogen atom, a C.sub.1 -C.sub.5 alkyl group or others; R.sup.3 represents a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group or others; R.sup.4 represents a hydrogen atom, a C.sub.1 -C.sub.3 alkyl group or others; R.sup.5 represents a group --OR.sup.42, a group ##STR2## or others.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6245810
Application Number:US1998000106454
Date Filed:30/06/1998
Date Published:12/06/2001
Assignee:Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai, Tokyo, Japan Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Japan


 
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