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| Title: | Amino acid derivatives |
| Inventors: | Ishizuka, Masaaki; Mishima, Japan Kawazu, Masaji; Numazu, Japan Katsumi, Toshiaki; Himeji, Japan Fuse, Yoshihide; Himeji, Japan Maeda, Kenji; Tokyo, Japan Takeuchi, Tomio; Tokyo, Japan |
| Summary: | Described herein are novel T-cell growth promoting amino acid derivatives such as immunomodulatory and anticancer agents and hematopoietic stem cell growth promoters. The invention relates to a novel amino acid derivative or a salt thereof and methods of their production via chemical synthesis. Claims of the invention include the ability of these new compounds to stimulate proliferation and physiological activities of T cells of mammals, as well as the ability to exhibit an immunomodulating activity as well as an antitumor activity or a carcinostatic activity. Further described is the property of these new compounds to stimulate the proliferation of hematopoietic stem cells. Precise sequences, formulae and chemical configurations are disclosed. |
| Abstract: | A novel amino acid derivative represented by the general formula (I) shown below or a salt thereof have now been provided by chemical synthesis, and it has been found that these new compounds stimulate proliferation and physiological activities of the T cells of mammals, have an immunomodulating activity and also have an antitumor activity or a carcinostatic activity. It has also been found that these new compounds have an effect of stimulating the proliferation of hematopoietic stem cells. ##STR1## wherein y is 0 or 1; R.sup.1 represents an unsubstituted C.sub.1 -C.sub.8 alkyl group or others; R.sup.2 represents a hydrogen atom, a C.sub.1 -C.sub.5 alkyl group or others; R.sup.3 represents a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group or others; R.sup.4 represents a hydrogen atom, a C.sub.1 -C.sub.3 alkyl group or others; R.sup.5 represents a group --OR.sup.42, a group ##STR2## or others. |
| US Patent Website: | Click Here for Full Text of Patent |
| Title Number: | US6245810 |
| Application Number: | US1998000106454 |
| Date Filed: | 30/06/1998 |
| Date Published: | 12/06/2001 |
| Assignee: | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai, Tokyo, Japan Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Japan |