Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6248587

Title:Method for promoting mesenchymal stem and lineage-specific cell proliferation
Inventors:Rodgers, Kathleen E.; Long Beach, CA, USA
DiZerega, Gere; Pasadena, CA, USA
Summary:Described herein are methods of promoting hematopoietic and mesenchymal stem cell proliferation and differentiation via a process of contacting the cells with angiotensinogen, angiotensin I or II, or analogues or fragments thereof. The invention relates to methods by which the proliferation of mesenchymal stem and lineage specific cells may be accelerated by a process involving contacting the mesenchymal stem and lineage-specific cells with an amount effective to accelerate proliferation of the mesenchymal stem and lineage-specific cells, involving at least one active agent comprising a sequence of at least six contiguous amino acids. Specific sequences and formulae are disclosed, as are therapeutic applications of such methods to a variety of diseases.
Abstract:The present invention fulfills a need in the art for methods that promote hematopoietic and mesenchymal stem and lineage-specific cell proliferation and differentiation by growth in the presence of angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II (AII), AII analogues, AII fragments and analogues thereof and AII AT.sub.2 type 2 receptor agonists.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6248587
Application Number:US1998000198806
Date Filed:24/11/1998
Date Published:19/06/2001
Assignee:University of Southern Cailfornia, Los Angeles, CA, USA


 
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